Magnetic
silica microspheres have become
increasingly imperative and popular for a variety of applications. They provide
combined advantages of working with bead platform and the unique properties of
a silica substrate, including: flexibility, large specific surface area,
improved binding kinetics over plane surfaces, robust statics, flexible
silanization chemistries, unique refractive index and density etc.
The
dimension of the magnetic
silica beads is the key factor for
the successful magnetic separation. It is usually less than 10 nano meter to
make sure perfect and selective interaction with biological objects. These
particles surface are modified with biocompatible inorganic or else organic
materials to both prevent aggregation caused by hydrophobic or else magnetic
attraction as well as facilitate the immobilization of specific ligands such as
antibody, aptamer, and DNA.
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| Magnetic Silica Microspheres |
The
magnetic microparticles have been attracted for use in bio application for
numerous years, due to advantages that they provide easily scalable,
time-efficient, cost-effective, and gentle separation of biological compounds
by using external magnetic field incline.
The
magnetic silica microspheres offered numerous exciting uses in biomedical field
as a solid support for
·
protein purification
·
besieged drug delivery
·
cell separation
·
medical diagnosis
·
immunoassays
·
DNA sequencing
·
and cell analysis
Various materials have been utilized for
matrices embedding super paramagnetic nano particles in the form of micro
beads. Despite wide-ranging efforts made by numerous research groups, the
demand for magnetic polymeric particles having uniform size, chemical
stability, user-defined magnetic contents, bio-compatibility, and the readily
tailor able surface is still escalating in potential application to biochips as
well as bio-separation. 
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